Neuraminidase Inhibitory Activities of Some Alcoholic Plant Extracts and Chemical Compounds

Abstract— In today’s world, disease rates are increasing day after day because of environmental factors, lifestyles and technology. Although there are many drugs for many diseases, people’s interest and demand for herbal products are increasing. So, plants that can be used in the treatment of diseases have to be researched scientifically. Neuraminidase belongs to a class of glycosyl hydrolases that release terminal sialic acid from glycoproteins, glycolipids and polysaccharides. Neuraminidases could be found in animals, microorganisms and viruses. They have an impact on pathogenicity. This enzyme which is required for viral replication is a surface glycoprotein in influenza types A and B. In this study, we examined the inhibitory effects of some plant extracts and chemical compounds on neuraminidase activity. The result of our experiments indicates that the neuraminidase inhibitory activities of plant extracts and chemical compounds increased in a dose-dependent manner. We can conclude that the plant extracts and chemicals/drugs can be used in pharmaceutical industries and drug treatment due to their neuraminidase inhibitory activities.