Strategies of N-Glycosidic Bond Cleavage by DNA Repair Enzymes

A. V. Endutkin^a (https://orcid.org/0000-0002-3647-6591) and D. O. Zharkov^a^,^b^, * (https://orcid.org/0000-0001-5013-0194)

^aInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia

^bNovosibirsk State University, Novosibirsk, 630090 Russia

Correspondence to: *e-mail: dzharkov@niboch.nsc.ru

Received 30 October, 2023

Abstract— DNA glycosylases are enzymes that hydrolyze the N-glycosidic bond of damaged nucleotides, initiating the process of base excision DNA repair. There are at least eight structural classes of these enzymes, differing in both their substrate specificity and the mechanism of catalysis. The review examines the mechanisms of human and bacterial DNA glycosylases that protect the genome from the major types of DNA damage.

Keywords: DNA damage, DNA repair, DNA glycosylases, catalytic mechanism

DOI: 10.3103/S0027131424700044