a Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
b Pharmaceutical Analysis Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
c Department of Chemistry, Arts and Science Faculty, Suleyman Demirel University, Isparta, 32260 Turkey
d Faculty of Pharmacy, Near East University, Nicosia, North Cyprus, 99138, Turkey
e College of Chemistry and Chemical Engineering, YangZhou University, YangZhou, Jiangsu, 225002 People’s Republic of China
f Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Correspondence to: *e-mail: rahimpour_e@yahoo.com
Received 1 December, 2022
Abstract— Solubility behavior of amlodipine besylate (ADB) was investigated in the binary mixtures of ethylene glycol + 2-propanol at five different temperatures (293.2–313.2 K). The solubility results obtained from the shake-flask method are correlated with some reported cosolvency models (i.e. the van’t Hoff, combined nearly ideal binary solvent/Redlich–Kister, the Jouyban–Acree, the Jouyban–Acree–van’t Hoff, the mixture response surface, the modified Wilson, and Buchowski–Ksiazczak models). The accuracy of these models is investigated with the mean relative deviations of the back-calculated solubility data.
Keywords: amlodipine besylate, solubility, cosolvency models
DOI: 10.3103/S0027131424010048