Synthesis and Biological Evaluation Studies of Novel 1,3,4-Oxadiazole and Benzo[d]imidazole Scaffolds as Promising Antimicrobial Agents

Abstract— We prepared a novel series of 1,3,4-oxadiazole and benzo[d]imidazolecontaining fi fteen new connections to develop potential antimicrobial agents (9a–9o). The structures of this new series were characterized by various spectral techniques like IR, ¹H NMR, ¹³C NMR, LC–MS, and elemental analysis. Using the Broth Dilution method, the hybrids were examined for antimicrobial activity against a variety of bacterial and fungal strains. Compound 9n (MIC = 50 μg/mL) exhibited good activity against gramnegative E. coli and compound 9m (MIC = 50 μg/mL) showed potent activity against P. aeruginosa. While compounds 9c, 9f, 9g and 9m indicated MIC = 250 μg/mL against C. albicans.