Russian Journal of Genetics: Applied Research. Vol. 7, No. 2, Pages 203-204, 2017

A. A. Belenko^a^,*, S. A. Vasilyev^a^,^b^,**, and I. N. Lebedev^a^,^b^,***
Translated by S. Khoronenkova

^bResearch Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, 634050 Russia

Correspondence to: *e-mail: greyden@sibmail.com
Correspondence to: **e-mail: stanislav.vasilyev@medgenetics.ru
Correspondence to: ***e-mail: igor.lebedev@medgenetics.ru

Abstract—The genotoxic effects of exposure to ionizing radiation during the early stages of human embryonic development can be fatal. Despite this, the radiosensitivity of human embryonic and differentiated extraembryonic cells is poorly studied. In this work, the efficiency of a DNA double-strand break repair in human extraembryonic fibroblasts was investigated. It was shown that the repair of radiation-induced DNA damage in human extraembryonic fibroblasts is likely to reflect the ability of these cells to repair spontaneous DNA double-strand breaks.

Keywords: γH2AX foci, micronuclei, DNA double-strand breaks, DNA repair, extraembryonic fibroblasts, individual radiosensitivity

Markers of the Individual Radiosensitivity of Human Extraembryonic Cells in vitro