Pineamin Increases Melatonin Synthesis
in Pineal Gland of Elderly People
S. V. Trofimovaa, N. S. Linkovaa, b, *, A. A. Klimenkoc,
T. V. Kvetnaiaa, and V. Kh. Khavinsona, d
Translated by L. Brovko
aSt. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, 197110 Russia
bPeter the Great St. Petersburg Technical University, St. Petersburg, 195251 Russia
cGeropharm Group of Companies, St. Petersburg, 191144 Russia
dPavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, 199034 Russia
Correspondence to: *e-mail: linkova@gerontology.ru
Abstract—The effect of a pineal gland polypeptide complex, Pineamin, on urine excretion of 6-sulfatoxymelatonin (6-SOMT) was investigated by immunoenzyme assay in 55 elderly patients with decreased melatonin formation. Pineamin at a dose of 100 mg increased the level of 6-SOMT excretion in overnight urine by 1.9 times in comparison with the respective indicator before the treatment. A similar effect was previously obtained upon the administration of Epitalamin, which also facilitated the restoration of melatonin synthesis in human and animal pineal glands affected by aging. Hence, Pineamin and Epitalamin exhibit a one-directional stimulating property with respect to the melatonin-forming function of the pineal gland in elderly people.
Keywords: Pineamin, 6-sulfatoxymelatonin, pineal gland, aging
DOI: 10.1134/S2079057017040130