Age Features Peripheral Erythron Rats and Its Status with Experimental Cardiosclerosis

Abstract—The features of the peripheral erythron in rats 4, 12, and 24 months old were studied. Each age group (n = 20) consisted of 10 intact animals and 10 animals with postinfarction cardiosclerosis (PICS). In the group of 24-month-old animals, an increase in the number of erythrocytes and the absence of difference in the number of reticulocytes was found. Expressed anisocytosis and decrease in hemoglobin synthesis in animals of this age group suggests age-related disorders in maturation of erythroid cells. The development of postinfarction myocardial remodeling has not affected erythropoiesis typical for the animals of the older age group. At the same time, a significant increase in the reticulocyte count in the peripheral blood smears was observed for this group of animals. The development of PICS in the marginal age groups of the animals leads to a smoothing of the difference between age groups noted in the animals in the intact state.