Age-Related Changes in Microcirculation
in the Cortex of Hypertonic Rats
I. B. Sokolovaa, I. V. Sergeeva, O. R. Fedotovaa, N. N. Melnikovaa, and D. P. Dvoretskya
Translated by E. Suleimanova
aI.P. Pavlov Institute of Physiology, St. Petersburg, 199034 Russia
bResearch Institute of Experimental Medicine, Northwest Branch, Russian Academy of Sciences,
St. Petersburg, 197376 Russia
Correspondence to: e-mail: sib@kolt.infran.ru
Abstract—We have studied the density of the microvascular system of the pia matter and perfusion and oxygen saturation of the sensorimotor cortex in hypertonic rats of different ages. We have found that the density of the microvascular system did not decrease, but increased, with age. The perfusion of the cortex decreased, and oxygen saturation of brain tissues increased. By the age of 12 months, the exploratory behavior of rats in an open-field test worsened significantly by all parameters.
Keywords: brain, aging, hypertension, microcirculation, perfusion, behavior
DOI: 10.1134/S2079057017010143