The Role of Circadian Rhythms and the “Cellular Clock” in Age-Associated Diseases

A. V. Panchenko^a^,^b^,*, E. A. Gubareva^a, and V. N. Anisimov^a
Translated by N. Tarasyuk

^aPetrov Research Institute of Oncology, pos. Pesochnyi, St. Petersburg, 197758 Russia

^bAlmazov Northwestern Federal Medical Research Center, St. Petersburg, 197341 Russia

Correspondence to: *e-mail: ando_pan@mail.ru

Abstract—Circadian oscillations are characteristic of almost all processes in living organisms. Disturbances in circadian rhythms may constitute either a cause or a consequence of different diseases. The article analyzes literature data on the role of changes in the circadian rhythms and the expression of clock genes in the development of neurodegenerative and cardiovascular diseases, metabolic syndrome, and type 2 diabetes mellitus in human beings and animals.

Keywords: circadian rhythms, сlock genes, сlock proteins, aging, neurodegenerative diseases, cardiovascular disease, type 2 diabetes mellitus

DOI: 10.1134/S2079057017010131