Glycation, Antiglycation, and Deglycation: Their Role in Aging Mechanisms and Geroprotective Effects (Literature Review)

V. V. Emel’yanov
Translated by L. Brovko

Ural Federal University named after the first President of Russia B.N. Yeltsin, Yekaterinburg, 620002 Russia

Correspondence to: e-mail: evvd@list.ru

Abstract—The biochemistry of glycation and its role in the disruption of cell metabolism and development of age-related pathologies have been reviewed in this manuscript based on literature data published, for the most part, in the last 5 years. The effects of antiglycation and deglycation actions of endogenous enzymes, as well as of exogenous chemical compounds of natural and synthetic nature on the process of aging, were evaluated.

Keywords: glycation, aging, advanced glycation end products, glycation inhibitors, advanced glycation end products breakers

DOI: 10.1134/S2079057017010064